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The Covid-19 pandemic caused the worldwide tourism industry to close. This reaction, diverse all the tourism stakeholders followed to make a revolutionary approach together with the virtual exhibition to preserve their sights firmly within the minds of potential site visitors in the virtual world. This looks at has incorporated the generation popularity model and protecting action selection version of the village and the culture to decide the factors that affect someone's decision to undertake virtual exhibition as temporary alternatives for the duration of times of crises. Information had been gathered from a sample of four hundred accessed when they had qualified as a minimum one of the Virtual exhibition of Flores exhibition records web sites. The conclusions show that the qualifications of the village and visuals are powerful in predicting customers to see the virtual exhibition, reason to undertake digital exhibition and that adoption reason has an excessive quality effect on the tendency to visit the real website. Likewise, realistic implications are provided for online site managers to remember when choosing virtual exhibitions as a promotional tool. © 2023 EDP Sciences. All rights reserved.
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Introduction: STAT1 gain-of-function (GOF) disease is associated with chronic mucocutaneous candidiasis (CMC) and a broad spectrum of infectious, inflammatory, and vascular manifestations. The Janus Kinase inhibitor ruxolitinib has been used successfully for CMC and autoimmune phenomena. We describe a case of warm autoimmune hemolytic anemia (WAIHA) in a patient with STAT1 GOF disease after initiating ruxolitinib. Case report: A 36-year-old man with STAT1 c.850G>A (p.Glu284Lys) mutation presented with CMC as well as recurrent viral and bacterial infections, lymphadenopathy, enteritis, nodular regenerative hyperplasia (NRH) and splenomegaly. Immune workup confirmed a combined immunodeficiency with hypogammaglobulinemia and T-cell lymphopenia. Ruxolitinib was initiated at 5 mg twice daily (due to pre-existing thrombocytopenia) with up titration over 3 months to 20 mg twice daily. He improved with weight gain, increased energy, resolution of chronic anemia, and improved lymphadenopathy and splenomegaly on imaging. Serum CXCL9 only minimally decreased from 4660 pg/ml to 3990 pg/ml. Soon after reaching ruxolitinib 20 mg twice daily, he developed JC viremia, prompting dose reduction to 15 mg BID. Within two weeks, he developed a non-COVID upper respiratory tract infection followed by fatigue, shortness of breath with ambulation, and dark urine. Emergency evaluation revealed warm antibody positive hemolytic anemia with a hemoglobin of 5 g/dL, and worsened thrombocytopenia. He was treated with blood transfusions, pulse steroids, and high-dose IVIG with stabilization but continued hemolysis. Due to the JC viremia, there was concern to give rituximab with increased PML risk. Bone marrow showed trilineage hematopoiesis, a mild increase in megakaryocytes and RBC precursors, and a loss of B-cell progenitors with retention of mature B cells. His B and T lymphocyte numbers had increased since prior to ruxolitinib, with a predominance of Tfh1-cells (58.7% of total Tfh-cells). He was started on sirolimus with a slow taper of prednisone with continued stable hemoglobin and platelets, and resolution of hemolysis after 3 months. Conclusion(s): To our knowledge, this is the first case of a STAT1 GOF patient developing WAIHA while receiving ruxolitinib therapy. Treatment choices were complicated by the risks of PML. Sirolimus combined with ruxolitinib allowed wean of corticosteroid and subsequent resolution of hemolysis.Copyright © 2023 Elsevier Inc.
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The corona virus pandemic has affected every industrial sector, and the construction industry is no exception. Construction project teams have been experiencing various disruptions due to the pandemic. Project team needs to develop concepts and methods of dealing with unexpected situations. In order to survive, the construction industry may need to practice the concept of resilience. A literature review suggests there are few studies on team resilience that focus on construction projects. Therefore, research is necessary to explore the conceptual realms of construction project team resilience. This study aims to develop a theoretical framework that establishes the interrelationships between determinants, team resilience, and project performance. The latest relevant theories on resilience are reviewed and adopted for the framework development. Ultimately the new framework could be used for subsequent empirical studies. © 2023 Author(s).
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SMEs have been the backbone of numerous economies all over the world. But since Covid-19 pandemic hit many economies, it changed practically every part and component of SMEs. In response to the pandemic, one transition has been accelerated, namely digital transformation. Although previous studies on digital transformation performed by SMEs in ASEAN countries have been conducted, currently, there is no single empirical study that compare digital transformation conducted by SMEs across ASEAN countries. Therefore, we discuss and reflect on the implementation of digital transformation by SMEs in ASEAN countries by reviewing existing empirical studies on SMEs' digital transformation published between 2020–2022 are reviewed. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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Increasing evidence suggests that activation of the complement system plays a key role in the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a systematic approach to create an overview of complement activation in COVID-19 based on histopathological, preclinical, multiomics, observational and clinical interventional studies. A total of 1801 articles from PubMed, EMBASE and Cochrane was screened of which 157 articles were included in this scoping review. Histopathological, preclinical, multiomics and observational studies showed apparent complement activation through all three complement pathways and a correlation with disease severity and mortality. The complement system was targeted at different levels in COVID-19, of which C5 and C5a inhibition seem most promising. Adequately powered, double blind RCTs are necessary in order to further investigate the effect of targeting the complement system in COVID-19.
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The Covid-19 pandemic is continuing and has an impact on changing lifestyles worldwide. Since mid-June 2020, Islamic boarding schools learning has been carried out with the blended method. The fundamental purpose of this study is to ascertain the santris' knowledge, attitudes, perceptions, and prevention behavior during the Covid-19 pandemic. The study used a cross-sectional design, with the population consisting of santris in Islamic boarding schools with varying educational levels and ages. Purposive sampling was used, and 833 respondents were selected. A questionnaire was used to conduct the online survey. Descriptive statistics were utilized to describe data retrieval results. The findings indicated that just a few respondents possess sufficient information regarding the indications, symptoms, and transmission of Covid-19;nevertheless, santris have a moderate level of knowledge regarding Covid-19 protection. The vast majority of santris believe Covid-19 affects their lives. However, Santris generally have less or negative information, attitudes, and impressions about Covid-19. As a result, government support is required for educational institutions to implement policies that increase santris' knowledge, attitudes, and perceptions of Covid-19. © 2023 American Institute of Physics Inc.. All rights reserved.
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Mathematics learning that needs to be taught of primary school teachers consists of selected math parts to develop abilities and shape the child's personality and is guided by the development of science and technology, wherein Numeration learning in the form of PISA type questions using the application of learning PMRI using Covid-19 context. The learning media that will be developed in this study will be assisted by the Universitas PGRI Palembang e-learning system named SISFO. By utilizing E-Learning, one of them is online learning during the Covid-19 pandemic. Data collection uses descriptive qualitative and continuous quantitative where the data is also described theoretically and also uses the calculation of results in numeracy learning which is applied to the mathematics learning development course of primary school teachers at Universitas PGRI Palembang. The purpose of this research is to produce an application of numeracy learning based on the characteristics and principles of PMRI. The data submission analysis technique is in the form of observation sheets and student learning outcomes tests in the form of documentation. The results of the study were in the form of observation scores from PMRI activities in numeracy learning and also in the form of student learning outcomes that were documented as a whole which had a positive impact on working on 10 questions of reasoning ability tests on numeration that had been tested for validity and reliability in learning to work on statistical content questions. © 2022 American Institute of Physics Inc.. All rights reserved.
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Mathematics learning that needs to be taught of primary school teachers consists of selected math parts to develop abilities and shape the child's personality and is guided by the development of science and technology, wherein Numeration learning in the form of PISA type questions using the application of learning PMRI using Covid-19 context. The learning media that will be developed in this study will be assisted by the Universitas PGRI Palembang e-learning system named SISFO. By utilizing E-Learning, one of them is online learning during the Covid-19 pandemic. Data collection uses descriptive qualitative and continuous quantitative where the data is also described theoretically and also uses the calculation of results in numeracy learning which is applied to the mathematics learning development course of primary school teachers at Universitas PGRI Palembang. The purpose of this research is to produce an application of numeracy learning based on the characteristics and principles of PMRI. The data submission analysis technique is in the form of observation sheets and student learning outcomes tests in the form of documentation. The results of the study were in the form of observation scores from PMRI activities in numeracy learning and also in the form of student learning outcomes that were documented as a whole which had a positive impact on working on 10 questions of reasoning ability tests on numeration that had been tested for validity and reliability in learning to work on statistical content questions. © 2022 American Institute of Physics Inc.. All rights reserved.
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Due to the decrease in GNI per capita, the Indonesian government has launched its national economic recovery program in response to the COVID-19 emergency crisis, known as the New Normal and ordered to partially resume on-hold infrastructure projects followed by the implementation of a new, integrated COVID-19 health protocol. This research presents a study of health protocol standard implementation in the construction industry with the aim of formulating recommendations for minimum criteria elements that can be used for construction services companies at all levels. The domain-taxonomy analysis approach was used as the research method: the ISO/PAS 45005:2020 and ILO standards were adapted to Ministerial Regulation of PUPR No. 10 Year 2020. A gap analysis was conducted with Singapore, Malaysia, and Australia. The analysis generated four segregated main groups of elements with level-2 sub criteria. The main groups of elements were: Planning, Prevention, Handling, and Control and Evaluation. These criteria were validated and implemented in a case study of state-owned construction enterprises, here called PT. X and PT. Y, with large, qualified construction companies. From the implementation analysis it was found that PT. X and PT. Y had implemented the minimum criteria of the COVID-19 health protocol for construction workers very well. © 2022 Published by ITB Institute for Research and Community Services.
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Clean air is a basic thing that is needed by living things. This makes clean air is very important for the continuity of life. Therefore, an air pollution standard index is needed to determine air quality based on the concentration of gas contained in it. As the State Capital which is the center of the economy, DKI Jakarta Province has an important air quality issue that needs to be controlled regularly. This research is a qualitative descriptive study of secondary data on the air pollutant standard index to compare the gas concentration parameters in the air before and during the COVID-19 pandemic. The results of the analysis show that during the COVID-19 pandemic there was an increase in the "good and moderate" category days and a decrease in the "unhealthy and very unhealthy" category days compared to before the COVID-19 pandemic. © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/)
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This study investigated the influence of Dynamic Capabilities (DC) and Digital Transformation (DT) on Business Resilience During the COVID-19 Pandemic. Using cross-sectional data from 388 micro, small, and medium enterprises (MSMEs) of beekeeping in Indonesia. Furthermore, the data were analyzed by Structural Equation Model (SEM) analysis and executed by SmartPLS 3.0 software. The main results of this study indicate that DC plays an important role in improving MSMEs' DT. However, the essential role of DT on firm resilience only happened for micro, small, and medium firms of family businesses. However, DT has an insignificant effect on firm resilience in small nonfamily businesses. Yet, the effect of DC on firm resilience is mediated by DT. Nevertheless, our empirical findings indicate heterogeneous effects among micro, small, and medium firms. Based on the study's findings, we suggested that the policy implication in developing beekeeping firms should be more specific based on the firm scale. The results of this study can be generalized to the national level to inform decision-making regarding the intangible assets of MSME livestock products in developing countries. The findings are also relevant to other livestock products, which tend to be dynamic during a crisis.
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The pandemic covid-19 has brought a change in the order of life, including the learning process. Technology becomes indispensable to accelerate the process of learning during the pandemic. One of the technology-based media that can be used is a mobile game. The purpose of this study is to explain why mobile game can be a medium for learning mathematics during the covid-19 pandemic based on the study of theory and results from previous research. The method used is a literature review. Data was obtained from scientific journals and books that have been published in reputable publishers, with a total of 25 papers. The results show that mobile game can be a medium for learning mathematics during the covid-19 pandemic because "cause and effect"of the advantage of mobile games and learning constraints during covid-19 pandemic. © 2022 Author(s).
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Heart rate and body temperature are some of the important components of a person's main vital signs that need to be monitored regularly and periodically. The detection system technology continues to develop which allows a person to detect his own condition, to avoid exposure to COVID-19. However, the tools that are developing in the market are quite expensive and sometimes complex in operation because they are external products, so that it becomes a difficulty in itself. For this reason, it is important to design a detection device with sensor components that exist in the country and with a simple design so that it is easy to operate and inexpensive. In this paper, utilizing pulse sensors and AD8232 sensors to detect heart rate and MLX90614 sensors to measure body temperature, then NodeMCU ESP8266 to process sensor signals received and will be forwarded to the Display (LCD) to display the results carry out the design and development of an integrated sensor system. From the research results, the accuracy of the MLX90614 temperature sensor is very good with the achievement of 99.24% and the pulse sensor with the achievement of 98.86%. For the test results on each sample obtained accuracy values of 98.4% and 99% for the temperature sensor, and 92.3% and 92.2% for the pulse sensor, respectively. From these results, it is very clear that the sensor design deserves to be promoted as a quality product. © 2022 IEEE.
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[This corrects the article DOI: 10.3389/fped.2021.716898.].
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Coronavirus causes Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), sometimes referred to Covid-19. The virus has a high duplication power to spreads and infects peoples. WHO has declared this illness an extraordinary pandemic. The symptoms of Covid-19 suffer within 14 day incubation period are as follows: fever, cough, shortness of breath or difficulty breathing, headache, runny nose, and sore throat. The government of Indonesia has instructed that the hospital is reserved only for severe Covid-19 patients, while patients with suspected Covid-19 are advised to be treated by the community. On the other hand, they need to know about patients' health data and monitor them without direct contact. Telehealthcare has been utilized for diagnosis, treatment, and avoidance of illness. IoT could be implemented in the healthcare area, and sensors could be used to measure the patient's physiological parameters to the server. The systems read vital signs such as body temperature, measurement of breathing, coughing, and heart rate. In this research, we propose an assistive technology that roled and played within the community services for the suspect patient. © 2022 IEEE.
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Handling the rapid spread of the Coronavirus that is currently engulfing the world is critical to suppress the development of the Coronavirus. one of them is rapid test distribution management. The rapid Test is an initial screening method for detecting antibodies, namely IgM and IgG, which are produced by the body to fight the Coronavirus / Antibodies that will be formed by the body when there is exposure to the Coronavirus. So, a rapid test is a screening tool, not an examination, to diagnose Coronavirus infection or COVID-19. For this reason, in current conditions, it is necessary to have a good arrangement in terms of distribution and regulation of the rapid test stock. Distributing the Corona (Covid 19) rapid Test prioritizes health facilities in areas that are the epicenter of the Corona spread. For this reason, this study provides a Rapid Test Using the Naïve Bayes Data Mining Algorithm. In this study, data obtained from data collection were then classified based on the framework used to conduct further analysis using the Simple Additive Weighting and Naive Bayes algorithm. This research results to determine the distribution of the rapid test tool based on stock data to be used for forecasting the distribution model. © 2022 IEEE.
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The COVID-19 pandemic has had an impact on every line of human life, including education. This study aims to analyze the application of online learning based on Electronic Scientific Discussion Group (ESDG) in the Biology Tadris Study Program, Faculty of Tarbiyah and Teacher Training, State Islamic University of North Sumatra. This study uses quantitative and qualitative research designs with research procedures including: collecting data, uniting data, reducing data with analytical techniques, and concluding the data findings. The research instrument used was in the form of observation sheets and interviews. The data were collected by interview and observation techniques, then the data were analyzed using inferential statistical techniques and the Miles and Huberman approach. The results of the study indicate that the application of ESDG is carried out in three learning series that are integrated in virtual learning. By applying ESDG student learning outcomes have increased with the highest increase in learning outcomes in the four observation classes of: 86.9%, 84.8%, 87.4%, and 88.2%. The results of the study can be concluded that the application of ESDG has a significant effect on improving learning outcomes in online learning. © 2022 American Institute of Physics Inc.. All rights reserved.
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Background: Remdesivir is one of the antiviral agents to treat COVID-19 infection. It has an antiviral activity directly related to activation of pro-inflammatory responses, causing cytokine storm, multiorgan damage and mortality. With these potential activities, this study investigated the effectiveness and evaluated side effects of remdesivir used for COVID-19 patients with pneumonia. Method(s): This cohort observational study collected data retrospectively from medical records of COVID-19 patients at Bhayangkara H.S Samsoeri Mertojoso Hospital, Surabaya. Patients who received remdesivir with loading dose (1 x 200 mg) IV had to follow maintenance dose (1 x 100 mg) IV. They were analyzed in three groups from October 2020 to February 2021. The data conveyed PCR/rapid Ag Swab, oxygen saturation, chest X-rays imaging, BUN, SCr, SGOT and SGPT. Result(s): A total of 60 patients were evaluated in three therapeutic groups, and the administration of remdesivir within 5-9 days was effective. Mostly, the patients (77%) had negative PCR/rapid Ag Swab;most of them (52%) had better oxygen saturation by supplementary oxygen therapy;more than a half had better chest X-rays imaging parameters (68%). Common side effects included an increase in SGOT (85.30%), SGPT (79.88%), BUN (74.23%), and serum creatinine (43.33%). Conclusion(s): The antiviral effect of remdesivir with loading dose (1 x 200 mg) IV needs to follow maintenance dose (1 x 100 mg) IV for 5-9 days. Hence, COVID-19 patients with pneumonia could have clinical improvement with increased level of liver and kidney function. Copyright © 2022, Institute of Medico-legal Publication. All rights reserved.
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Background: Lopinavir/ritonavir is an antiviral studied for its effectiveness in healing severe COVID-19 infection;however, it remains debated. This study determined the efficacy and evaluated the side effects of lopinavir/ ritonavir on severe COVID-19 patients with comorbid hypertension and diabetes mellitus. Method(s): Retrospective data collection was conducted from June to December 2020. The data were then analyzed descriptively. Severe COVID-19 patients with hypertension and diabetes mellitus who received lopinavir/ ritonavir were grouped into groups A, B, C, D and observed based on other pharmaceutical therapies (antibiotics, corticosteroids, anticoagulants, multivitamins and supplements, comorbid therapy, and symptomatic therapy) obtained. The efficacy of lopinavir/ritonavir was identifiable through RT-PCR, oxygenation saturation, and chest X-ray. The side effects of lopinavir/ritonavir were also be evaluated. Result(s): Only 21 total sample met the inclusion criteria. The oral administration of lopinavir/ritonavir (2 x 400/100 mg) was effective in groups A, B, C, and D whose negative RT-PCR results were respectively 10%, 48%, 5%, and 14%;normal oxygen saturation with the administration of oxygen therapy was 10%, 33%, 5%, and 5%, respectively;and chest X-ray improvement was 10%, 29%, 5%, and 14%, respectively. Lopinavir/ritonavir could increase SGOT (46%), SGPT (27%), as well as a QT interval prolongation (5%). Conclusion(s): The administration of lopinavir/ritonavir is effective to rule out negative RTPCR results, improve chest X-ray imaging and oxygen saturation. Monitoring side effects merits more attention to avoid those potential side effects of the therapies. Copyright © 2022, Institute of Medico-legal Publication. All rights reserved.
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Hospital workers were at high risk for SARS-Cov-2 infection and the first population with authorized access to the three doses of vaccination against SARS-Cov-2 antigen. The study was aimed to compare SARS-Cov-2 antibody levels among hospital workers receiving the three doses of Covid-19 vaccines with a history of Covid-19 infection versus those without a history of infection. A cross sectional study was conducted at the Sulianti Saroso infectious Disease Hospital (SSiDH) in December 2021. The inclusion criteria were hospital workers in both subjects with and without previous Covid-19 infection and those who had received 3 doses of Covid-19 vaccines. Anti SARS-Cov-2 antibody levels measured by the Architect of SARS-Cov-2 igG ii Quant. There were 75 participants in the study, the median of anti SARS Cov-2 levels reported 8724.4 AU/mL (3396.8, 15773.2 AU/mL, interquartile range). They were divided into 2 groups according to the status of prior Covid-19 infection, hospital workers with and without previous of Covid-19 infection. There was no significance difference in antibody less than 25.000 AU/mL between hospital worker with and without previous Covid-19 infection (p=1,000). Meanwhile, the median of antibody levels was seen in the interval between the 3rd dose of vaccine within 1 month;2 to 3 months;4 to 5 months before the antibody measurement (14576.5 AU/mL;12407.4 AU/mL;5778.1 AU/mL, respectively). in this study, after three doses of Covid-19 vaccines, there was no significance difference in antibody levels of hospital worker with and without previous Covid-19 infection. Copyright © 2022 Oriental Scientific Publishing Company. All rights reserved.